Antidiabetic Effects of Omega-3 Polyunsaturated Fatty Acids: From Mechanism to Therapeutic Possibilities
نویسندگان
چکیده
Diabetes mellitus (DM) is chronic disease characterized by hyperglycemia and insulin resistance caused by dysfunction of pancreatic β cells. Over the past few decades, epidemiological studies have suggested that dietary long-chain polyunsaturated fatty acids such as docosahexaenoic acid and eicosapentaenoic acid decrease the risk of metabolic diseases including DM. The mechanisms underlying the therapeutic efficacy of dietary long-chain polyunsaturated fatty acids in treating DM have been partly revealed. In this review, the authors describe the antidiabetic effects of longchain polyunsaturated fatty acids and also discuss their possibilities as therapeutics for DM in the light of recent findings.
منابع مشابه
Zooplankton and their protective effects on cardiovascular diseases
In the world-wide cardiovascular diseases are the most common. And mortallities are high. Many modifiable and non-modifiable risk factors for cardiovascular diseases have been identified. One of them is diets. In diet polyunsaturated fatty acids such omega-3 and omega-6 have protective effects on cardiovascular health. Polyunsaturated fatty acids are essentials for humans, have taken from foods...
متن کاملEvaluation of the Relationship between Endometriosis and Omega-3 and Omega-6 Polyunsaturated Fatty Acids
Background: Endometriosis is a common chronic inflammation causing major problems including infertility. The role of omega-3 and omega-6 fatty acids as their potential anti-inflammatory effects in endometriosis needs to be further explored. The objective of this study was to compare serum phospholipid fatty acid profile in endometriosis patients with controls, and to explore the correlation of ...
متن کاملEffects of seasonal variations on fatty acid content of muscle in Pampus argenteus caught from Persian Gulf
Since fish have large amounts of long chain polyunsaturated fatty acids, they are considered a good source of food. In this study, fatty acid content and proximate composition of Silver Pomfret fish (Pampus argenteus) were investigated during winter and summer. For this purpose, the samples were collected from Bandar Lenge of Persian Gulf in 2016 and brought to the laboratory. The moisture, fat...
متن کاملReview Article: The importance of Omega-3 fatty acids in fish on human health
Heart failure (HF) incidence increases worldwide and is affected by various risk factors such as coronary artery disease, hypertension, obesity, and diabetes. Dietary recommendations for patients with HF have generally focused on sodium restriction; however, different nutritional approaches are considered in patients with a high risk of malnutrition due to the diuretic drugs they use. Omega-3 f...
متن کاملThe effect of omega- 3 polyunsaturated fatty acids on endothelial tight junction occludin expression in rat aorta during lipopolysaccharide-induced inflammation
Objective(s): Occludin is essential for proper assembly of tight junctions (TJs) which regulate paracellular endothelial permeability. Omega-3 polyunsaturated fatty acids (Ω-3 PUFA) protect endothelial barrier function against injury. Materials and Methods: We examined anti-inflammatory effect of Ω-3 PUFA intake (30 mg/kg/day for 10 days) on expression and location of occludin in the aorta of ...
متن کامل